Running an ASP.NET using dynamically loaded assemblies

How could I run an IIS express website using purely dynamically generated assemblies and webconfigs.

For example, I could dynamically run a Console Application by doing:

Assembly pAssembly = Assembly.LoadFrom([[ApplicationPath]]).

MethodInfo pMainMethod = pAssembly.GetType("Program").GetMethod("Main);

pMainMethod.Invoke(null, new Object[1] { new String[0]; });

I can even dynamically load the app config using something like in this question: Change default app.config at runtime

How could I do something similar for dynamically running an IIS express website using dynamically generated assemblies (these assemblies might not necessarily be on the file system, since they may have been fetched remotely).